Chromosomal abnormalities and its relevance to survival time in diffuse large B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2012.04.009
- VernacularTitle:弥漫大B细胞淋巴瘤患者染色体改变及其与生存期的关系
- Author:
Feng ZHU
;
Luqin ZHANG
;
Yulin GUO
;
Wei ZHU
;
Weijun GU
- Publication Type:Journal Article
- Keywords:
Lymphoma,Large B-cell,diffuse;
Chromosome aberrations;
Survival time;
Clinical stages
- From:
Journal of Leukemia & Lymphoma
2012;21(4):225-227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between chromosomal abnormalities of diffuse large B-cell lymphoma and its survival time.Methods Chromosome preparations were made by using modified method.Karyotypes were analyzed by stain of G-banding. And all patients were treated by chemotherapy. All patients' survival time was calculated.Results Mitotic cells that could be used for analysis were found in 28 cases.5 of 28 karyotypes were normal and 8 cases were polyploid.There were 4 cases with t(14,18)(q32;q21),5 cases with t(3; 14) (q27;q32),2 cases with t(2;3) (p11 ;q27),1 case with t(3 ;22) (q27 ;q11) respectively.There were 2 cases with ectopia between 7 chromosome and other chromosomes and 1 case with ectopia between 17 chromosome and other chromosomes.The survival time of patients with normal karyotype,t(14,18) (q32;q21)or 3q+ was longer than that of other groups.The survival time of group in Ⅰ, Ⅱ stages was longer than that in Ⅲ, Ⅳ stages. Conclusion The treatment, survival time and prognosis could be expected according to chromosomal abnormalities and its relevance to stages in diffuse large B-cell lymphoma.
