Relationship between CD_(44v) and leukemia
10.3760/cma.j.issn.1009-9921.2010.03.020
- VernacularTitle:CD_(44v)与白血病的关系
- Author:
Jie YANG
;
Hongling HAO
- Publication Type:Journal Article
- Keywords:
CD_(44v),;
Leukemia
- From:
Journal of Leukemia & Lymphoma
2010;19(3):184-187
- CountryChina
- Language:Chinese
-
Abstract:
CD_(44) adhesion molecule is a cell surface transmembrane glycoprotein.It displays many varinat isoforms generated by alternative splicing of exons, including CD_(44s). and CD_(44v). It has been reported that CD_(44) adhesion molecule is strongly expressed on the surface of leukemic blasts in all acute myeloid leukemia subtypes.It has been found through in vitro study that CD_(44) monoclonal antibodies can inhibit proliferation of all acute myeloid leukemia cell lines and induce terminal differentiate or apoptosis of some cell lines to diverse extent. In this review the relationship between CD_(44v), and leukemia was analysed.
