Studies on the pathogenesis of primary myelofibrosis
10.3760/cma.j.issn.1009-9921.2009.10.021
- VernacularTitle:原发性骨髓纤维化发病机制研究进展
- Author:
Ling PAN
- Publication Type:Journal Article
- Keywords:
Myelofibrosis;
Polycythemia,vera;
Thrombocytosis
- From:
Journal of Leukemia & Lymphoma
2009;18(10):638-640
- CountryChina
- Language:Chinese
-
Abstract:
In the past decades, genetic lesions, aberrant epigenetic modifications, progenitor colonies formations and cell cycle distribution have been the focus of studies on the pathogenesis of primary myelofibrosis (PMF). The relative results showed that PMF is a clonal proliferative disease of hematopoietic stem cells. Now it is defined that primary myelofibrosis, polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloprolfferative neoplasmas(CMPN).
