Expression and clinical significance of stromal cell-derived factor-1 and its receptor CXCR4 in leukemia
10.3760/cma.j.issn.1009-9921.2009.01.023
- VernacularTitle:基质细胞衍生因子-1及其受体CXCR4在白血病中表达的临床意义
- Author:
Chen CHEN
;
Hao SHI
- Publication Type:Journal Article
- Keywords:
Leukemia;
Chernotactic;
Factors;
Receptors,G-protein-coupled
- From:
Journal of Leukemia & Lymphoma
2009;18(1):57-59
- CountryChina
- Language:Chinese
-
Abstract:
Stromal cell-derived factor-1(SDF-1)is an early cell growth factor which belongs to a subfamily of chemokines.The CXCR4 is SDF-1 receptor.The SDF-1 interacting with CXCR4 plays important roles in physiological and pathological processes such as hematopiesis, stem cell homing,angiogenesis and leukemic cells infiltrating.To study the expression of CXCR4 in leukemia and the relationship between CXCR4 and leukemic cells infiltration can add indicators for leukemic MIC diagnosis of immunology indexes and have great significance to take molecule targeted therapy for preventing leukemia from infiltration or relapse as well.
