Expression of Hepatocyte Growth Factor in Pulmonary Embolism
10.3969/j.issn.0253-9896.2009.12.015
- VernacularTitle:肝细胞生长因子在急性大鼠肺栓塞中的表达
- Author:
Yuezhong YANG
;
Yangsheng YU
;
Wenxin HUANG
;
Tongtong XU
;
Jianyi ZHANG
;
Quanzhong LI
- Publication Type:Journal Article
- Keywords:
hepatocyte growth factor pulmonary embolism models;
animal in situ hybridization rats;
Sprague-Dawley
- From:
Tianjin Medical Journal
2009;37(12):1038-1040
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expression of hepatocyte growth factor(HGF) in acute pulmonary embolism, and the diagnostic value of HGF thereof. Methods: The acute autoblood pulmonary thromboembolism was used to establish rat pulmonary embolism model. There were blood plasma HGF detection group,organization HGF mRNA detection group and control group respectively. The expressions of plasma HGF and organization HGF were observed during the different periods of acute pulmonary embolism. Results:The expression of HGF was much higher in blood plasma HGF detection group than that of control group at different time points(P ＜ 0.01). The expression of HGF mRNA increased in organization HGF detection group compared with that of control group at 12 h after pulmonary embolism(P ＜ 0.01). Conclusion: The expression of HGF increased in acute pulmonary embolism, which can be used as a diagnosis indicator in acute pulmonary embolism.
