Effects of Point Application on Celiac Mast Cell Degranulation in Mice with Allergic Rhinitis: An Experimental Study
10.1007/s11726-010-0075-y
- VernacularTitle:Effects of Point Application on Celiac Mast Cell Degranulation in Mice with Allergic Rhinitis: An Experimental Study
- Author:
Jie CHEN
;
Xinsheng LAI
;
Chunzhi TANG
;
Lilei HE
;
Bingxu JIN
;
Xuejun CUI
- Publication Type:Journal Article
- Keywords:
Acupoint Sticking Therapy;
Allergic Rhinitis;
Mast Cells;
Mice
- From:
Journal of Acupuncture and Tuina Science
2010;8(2):75-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate effects of different treatment on celiac mast cell degranulation in mice with allergic rhinitis induced with ovum albumin (OVA).Methods:60 female mice were randomly divided into five groups,12 mice in each,which were treated with different methods.Then,the celiac mast cells were separated and degranulation rate was calculated after stained with neutral red.Results:the rates of mast cell degranulation were (15±6)%,(53±11)%,(37±13)%,(31±15)%,and (47±14)% in normal group,OVA group,point application group,hormone group,and PBS group.There is obvious degranulation in the celiac mast cells of mice with OVA-induced allergic rhinitis.Point application and dexamethasone treatment could relieve the mast cell degranulation,whereas,PBS has no effect on the mast cell degranulation.Conclusion:the mechanism of antianaphylaxis of point application may lie on stabilizing the mast cell membrane,and inhibiting degranulation to reduce the inflammatory mediator.
