Expression and correlation of survivin, COX-2 and bcl-2 in non-Hodgkin lymphoma

VernacularTitle:survivin、环氧化酶-2及bcl-2在非霍奇金淋巴瘤中的表达及其相关性
Author: Huifang XIAO ; Xiongpeng ZHU ; Yijio ZHANG ; Debin LIU ; Wenqian XU ; Chuntuan LI ; Pengliang XIN
Publication Type:Journal Article
Keywords: Lymphoma,non-Hodgkin; Cyclooxygenase 2; Genes,bcl-2; Survivin
From: Journal of Leukemia & Lymphoma 2011;20(10):608-611
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the expression of survivin,COX-2 and bcl-2 in non-Hodgkin lymphoma(NHL)and the significance and correlation between them.MethodsImmunohistochemistry MaxVision systems for survivin,COX-2 and bcl-2 were conducted on 44 NHL and 20 reactive lymphoid hyperplasia (RH).ResultsThe positive expression rates of survivin,COX-2,bcl-2 in NHL were 70.45 ％(31/44),68.18 ％ (30/44),63.64 ％ (28/44),respectively,and these in RH were 40.00 ％ (8/20),40.00 ％(8/20) and 20.00 ％ (4/20),respectively.There was positive correlation between the expression of COX-2 and survivin (r =0.306,P =0.043),survivin and bcl-2 protein (r =0.339,P =0.040) in NHL.ConclusionCOX-2,survivin,bcl-2 are highly expressed in NHL.To detect the expression of them has clinical value to diagnosis NHL and to estimate the malignant degree of lymphoma.There are a positive correlations between the expression of COX-2 and survivin protein,and between the expression of survivin and bcl-2 protein,which indicates that they may play a synergistic role in the occurrence and development of NHL.