Expression of PTEN protein and clinical significance in diffuse large B lymphomas
10.3760/cma.j.issn.1009-9921.2010.04.003
- VernacularTitle:弥漫大B细胞淋巴瘤中PTEN蛋白表达的临床意义
- Author:
Shuna YAO
;
Yanyan LIU
;
Yan ZHAO
;
Zhihua YAO
;
Yanzhao JIA
;
Jie MA
;
Qingxin XIA
;
Shujun YANG
- Publication Type:Journal Article
- Keywords:
PTEN phosphohydrolase;
Lymphoma,large cell,diffuse;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2010;19(4):200-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study PTEN protein expression and clinical significance in patients with diffuse large B cell lymphoma. Methods Immunohistochemical staining was used to determine the PTEN protein expression in 40 cases of primary diffuse large B lymphoma tissuse. The results were analyzed by Kaplan-Merie survival analysis, Log-Rank test and Logistic regression analysis. Results PTEN protein was positive in 16 cases and negative in 24 cases. There was no significant difference between two groups in twoyear overall survival rate(62.5 % vs 66.7 %, P >0.05). Survival analysis showed that patient' s survival time gradually were reduced with extended time between PTEN protein-positive group and negative group, lower in PTEN-positive group than the negative group, but there was no significant difference in survival curve (P >0.05) in the two groups. We compared characteristics of patients between PTEN protein positive and negative groups,including molecular type, patient' s age, stage, LDH, physical score and extranodular invasion, there was no significant difference among them. PTEN protein was not correlated with prognosis, while International Prognosis Index(IPI) was still a risk factor (OR >1). Conclusion PTEN protein expression may not predict the outcome in diffuse large B cell lymphoma, but IPI still is a predictor.
