Research progress of Epstein-Barr virus-positive diffuse large B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2011.10.022
- VernacularTitle:EB病毒阳性老年人弥漫大B细胞淋巴瘤研究进展
- Author:
Jianchen FANG
- Publication Type:Journal Article
- Keywords:
Herpesvirus 4,human;
Lymphoma,B-cell;
Aged
- From:
Journal of Leukemia & Lymphoma
2011;20(10):631-634
- CountryChina
- Language:Chinese
-
Abstract:
Epstein-Barr virus-positive (EBV-positive) diffuse large B-cell lymphoma (DLBCL) of the elderly is a newly described lymphoproliferative disorder recently in the most current WHO classification of tumours of haematopoietic and lymphoid tissues.The objective of this review is to provide a thorough and current summary of the existing knowledge of this subtype of DLBCL. It will review and discuss the pathogenesis behind EBV-driven malignant transformation of B cells,the distinct pathologic characteristics of EBV-positive DLBCL,the potential predictive and prognostic value of EBV tumoral status in patients with DLBCL,and potential strategies for the treatment of this rare entity.
