Chemotherapy combined with involved-field radiotherapy for early-stage Hodgkin lymphoma: effects on outcome and long-term complications

VernacularTitle:早期霍奇金淋巴瘤化疗后受累野照射对疗效和长期毒副作用的影响
Author: Ningning LU ; Yexiong LI
Publication Type:Journal Article
Keywords: Hodgkin disease; Involved-field; Radiotherapy,computer-assisted
From: Journal of Leukemia & Lymphoma 2010;19(8):460-465
CountryChina
Language:Chinese
Abstract: Early-stage Hodgkin Lymphoma(HL) is curable by extended-field radiotherapy alone. To reduce the long-term toxicities and complications with similar overall survival, randomized controlled trials of combined-modality therapy have been investigated nearly two decades. Recent years, many large-scale randomized controlled trials showed superior disease-free survival of combined-modality treatment compared with radiotherapy or chemotherapy alone for early-stage classical HL. Thus, short-course chemotherapy plus involved-field and low-dose radiotherapy is the standard treatment for early-stage HL. With this regimen,several studies have been proved that long-term complications had been reduced, but long-time results should be awaited.