Expression and clinical significance of inhibitor of apoptosis protein XIAP in chiIdhood acute leukemia

VernacularTitle:凋亡抑制蛋白XIAP在儿童急性白血病中的表达及其临床意义
Author: Yanping ZHANG ; Taixin SHI ; Huiping ZHANG ; Shuyu LI ; Yanli SUN
Publication Type:Journal Article
Keywords: Inhibitor of apoptosis proteins; Child; Leukemia
From: Journal of Leukemia & Lymphoma 2008;17(6):445-447
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and clinical significance of inhibitor of apoptosis protein XIAP in childhood acute leukemia(AL).Methotis The expression of XIAP protein was detected by immunohistochemical assay in 54 children with AL.including 26 newly diagnosed and untreated AL children.23 children in remission and 5 relapsed.The eontrol included 10 children with normal bone marrow.Results The level of XIAP proteins in the bone marrow of newly diagnosed AL children was higher than that in remission and normal controls(P＜0.05),compared with that in relapsed children,with no statistical difference(P＞0.05).The level of XIAP protein in remission was higher than that in normal controls(P＜0.05).The level of XIAP protein in ALL and ANLL in newly diagnosed AL children was compared. with no statistical difference(P＞0.05).Conclusion The higher expression of XIAP may contribute to the pathogenesis and the progress of the childhood AL.