Maternal Serum and Amniotic Fluid Inhibin A Levels in Women who Subsequently Develop Severe Preeclampsia.
10.3346/jkms.2006.21.3.452
- Author:
Shin Young KIM
1
;
Hyun Mee RYU
;
Jae Hyug YANG
;
Moon Young KIM
;
Hyun Kyong AHN
;
Joong Sik SHIN
;
Jun Seek CHOI
;
So Yeon PARK
;
Jin Mi KIM
;
Bom Yi LEE
;
Do Jin KIM
Author Information
1. Laboratory of Medical Genetics, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hmryu@yahoo.com
- Publication Type:Original Article
- Keywords:
Pre-Eclampsia;
inhibin A;
Biological Markers;
Serum Marker;
Maternal Serum;
Amniotic Fluid
- MeSH:
Risk Factors;
Pregnancy Trimester, Second;
Pregnancy Outcome;
Pregnancy;
Pre-Eclampsia/*blood/*metabolism;
Middle Aged;
Maternal Age;
Inhibins/*biosynthesis/*blood;
Humans;
Gestational Age;
Female;
Case-Control Studies;
Amniotic Fluid/*metabolism;
Amniocentesis;
Adult
- From:Journal of Korean Medical Science
2006;21(3):452-456
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to evaluate whether maternal serum (MS) and amniotic fluid (AF) inhibin A levels are elevated in patients who subsequently develop severe preecalmpsia, and to investigate the correlation between MS and AF inhibin A levels in the second trimester. The study included 40 patients who subsequently developed severe preecalmpsia and 80 normal pregnant women. Inhibin A levels in MS and AF were measured with enzyme-linked immunosorbent assay (ELISA). The MS and AF inhibin A levels in patients who developed severe preeclampsia were significantly higher than those in the control group (both for p<0.001). There was a positive correlation between MS and AF inhibin A levels in patients who developed severe preeclampsia (r=0.397, p=0.011), but not in the control group (r=0.185, p=0.126). The best cutoff values of MS and AF inhibin A levels for the prediction of severe preeclampsia were 427 pg/mL and 599 pg/mL, respectively; the estimated ORs that were associated with these cut-off values were 9.95 (95% CI 3.8-25.9, p<0.001) and 6.0 (95% CI 2.3-15.8, p<0.001). An elevated level of inhibin A in MS and AF at the time of second trimester amniocentesis may be a risk factor for the subsequent development of severe preeclampsia.
