Clinical study on modified GMALL protocol for adult acute lymphoblastic leukemia

VernacularTitle:改良的德国多中心成年人急性淋巴细胞白血病研究组方案临床应用研究
Author: Yongsheng HAN ; Zimin SUN ; Weibo ZHU ; Xiaoyan CAI ; Jingsheng WU ; Xin LIU ; Huilan LIU ; Huizhi YANG
Publication Type:Journal Article
Keywords: Leukemia,lymphocytic,acute; Adult; Antineoplastic combined chemotherapy protocols
From: Journal of Leukemia & Lymphoma 2011;20(3):168-171
CountryChina
Language:Chinese
Abstract: Objective To analyze the treatment efficacy and safety of a modified GMALL protocol for adult acute lymphoblastic leukemia (ALL). Methods Data of 37 patients with newly diagnosed adult ALL treated with a modified GMALL protocol from January 2005 to December 2009 were retrospectively analyzed,and compared with that of 44 patients treated with an in-house conventional protocol at the same period.Results The complete remission (CR) rate was 89.2 %(33/37) treated with modified GMALL protocol. The cumulative overall survival (OS) rates at 1 year, 2 years, 3 years and 4 years were 77.5 %, 48.0 %, 40.0 %and 40.0 %, respectively. The main adverse events were grade 3 or grade 4 hematological toxicities and infections which were easily managed, and the treatment-related mortality rate was low. The OS of modified GMALL protocol was superior to that of the conventional protocol. Conclusion The modified GMALL protocol has a satisfying effect and the adverse events can be tolerated for adult ALL, so its clinical application can be encouraged.