Diffusion tensor imaging for gliomas grading at 3.0T MR: Analysis of apparent diffusion coefficient and fractional anisotropy

VernacularTitle:脑胶质瘤术前3.0T 磁共振弥散张量成像分级
Author: Zixiao LI ; Jianping DAI ; Tao JIANG ; Shaowu LI ; Guilin LI ; Yongjun WANG
Publication Type:Journal Article
Keywords: Brain neoplasms; Diagnostic imaging; Magnetic resonance imaging; Diffusion tensor imaging
From: Chinese Journal of Medical Imaging Technology 2009;25(12):2201-2204
CountryChina
Language:Chinese
Abstract: Objective To assess the value of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) value at 3.0T diffusion tensor imaging (DTI) in glioma grading before operation. Methods DTI was performed on 104 patients with histologically proved glioma. ADC, FA and DWI maps were produced, and ADC, FA value of solid tumors were measured and compared with the WHO classification of gliomas. Results Fifty-eight gliomas were WHO Ⅱ, 25 were WHO Ⅲ and 21 were WHO Ⅳ. The ADC value of WHO Ⅳ (0.81±0.20)×10~(-3)mm~2/s was lower than that of WHO Ⅲ [(1.05±0.30)×10~(-3)mm~2/s] and WHO Ⅱ[(1.26±0.32)×10~(-3)mm~2/s (P=0.008, P＜0.001)]. The ADC value of WHO Ⅲ was lower than that of WHO Ⅱ (P=0.003). The FA value of WHO Ⅳ (0.18±0.06) was higher than that of WHO Ⅱ (0.15±0.06) (P=0.046). No significance of FA was found between WHO Ⅲ (0.15±0.10) and Ⅱ, nor WHO Ⅳ and Ⅲ. Conclusion ADC and FA value can distinguish different grade gliomas. It is useful in deciding the surgical strategy and predicting the patient's prognosis.