Effects of FLAG regimen in treatment refractory and relapsed acute myeloid leukemia
10.3760/cma.j.issn.1009-9921.2009.04.014
- VernacularTitle:FLAG方案治疗难治复发急性髓系白血病13例
- Author:
Fang ZHAO
;
Rong CHEN
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid;
Drug therapy,combination;
Hematopoietic stem cell transplantation
- From:
Journal of Leukemia & Lymphoma
2009;18(4):228-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects, duration of hematopeietic depression and side effects of FLAG regimen for refractory and relapsed acute myeloid leukemia(AML). Methods 13 cases for 5 days, and granulocyte colony stimulating factor G-CSF 300 μg/d from day 0 till neutruphil recovery (ANC≥1x109/L). 13 patients were 8 males and 5 females. The median age was 41.8 years(range 28-67). It includes 5 relapsed AML patients and 8 refractory AML patients. Results Of the 17 times, 11 showed response to therapy; the rate of complete remission was 35.3 %(6/17); the rate of partial remission was 29.4 % (5/17) and the overall response rate was 64.7 %. Main toxicities were gastrointestinal side effects, myelosupression and the function of liver was lightly damaged. Neutropenia at lowest number began at the time of 5-12 days after regimen initiating and last 7-34 days, thrombocytopenia began at the time of 5-13 days and last 8-30 days. Conclusion FLAG regimen showed obvious effects for refractory and relapsed AML Most patients gained chance for hematopoietic stem cell transplantation. Hemotological and nonhemotological toxicities are acceptable.