Clinicopathology analysis of diffuse large B-cell lymphoma

VernacularTitle:弥漫性大B细胞淋巴瘤临床病理分析
Author: Fenhua LIANG ; Gangping WANG ; Jingzhong XU
Publication Type:Journal Article
Keywords: Lymphoma,large-cell,diffuse; Pathology,clinical; Immunohistochemistry; Diagnosis,differential
From: Journal of Leukemia & Lymphoma 2010;19(8):489-491
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinicopathological characteristics and immunopheotype of diffuse large B-cell lymphoma (DLBCL) in order to improve diagnosis and therapy efficacy. Methods The clinical, immunophenotypical and histopathological features of 22 cases of DLBCL patients were studied retrospectively. The expressions of CD20, CD30, CD10, bcl-6, MUM-1, Ki-67 and CD3o of all patients, and CD5,CyclinD1, Lysozyme,AE1/3 and PLAP of patients with differential cancer, seminoma, anaplastic large cell lymphoma and blastic variant of mantle cell lymphoma were detected by EnVision Immunohistochemical technique. Results All patients were primary systemic DLBCL. All of 22 patients, 14 males and 8 females,average 48(21-71) years old, were primary DLBCL, including 13 cases of germinal centre B-cell-like(GCB) (7 cases of intra-node and 6 extra-node) and 9 cases non-GCB (6 intra-node and 3 extra-node). Conclusion The favorable diagnosis of DLBCL may be achieved by combination of clinical histological and immunological features.