Effect of Formula Granule of Siwu Drugs on Sex Hormone and Its Receptor in Bone Marrow Depressed Mice
10.3969/j.issn.0253-9896.2009.07.017
- VernacularTitle:四物汤配方颗粒对骨髓抑制小鼠性激素及其受体影响的实验研究
- Author:
Mingzhao JIA
;
Qing XIA
;
Zhiwei CHEN
- Publication Type:Journal Article
- Keywords:
SIWU DECOCTION;
bone marrow diseases;
mice;
gonadal steroid hormones;
receptors,estrogen;
receptors,androgen;
radioimmunoassay;
immunohistochemistry
- From:
Tianjin Medical Journal
2009;37(7):578-580
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of abstracted formula granule of Siwu drugs on the sex hormones and expressions of androgen receptor (AR)and estrogen receptor (ER) in bone marrow depressed mice. Methods: One hundred and eighty mice (90 male and 90 female) were randomly divided into 6 groups. The effects of the formula granule of Siwu on sex hormones and expressions of AR and ER were explored by SABC method in bone marrow of depressed mice. Results: For the male rats, the levels of androgen were increased in male of treatment groups compared with those of model groups (P＜0.05), and the levels of estrogen were decreased in male of treatment groups compared with those of model groups (P＜0.05).For the female rats, the levels of androgen were increased in female of treatment groups compared with those of model groups,but no significant differences (P＞0.05), and the levels of estrogen were decreased in femal of treatment groups compared with those of model groups (P＜0.05). There was a dose dependent manner between treatment groups. Conclusion: The results suggested that formula granule of Siwu drugs may play a role in the hematopoietic function to repair bone marrow depression by improving AR and the balance of estrogen / androgen in mice.
