Comparitive study between compatriots HLA in the same period and haploidentical family donor allogeneic peripheral blood stem cell transplantation for the treatment of hematologic malignancies

VernacularTitle:同期同胞HLA全相合与亲缘间单倍体相合异基因造血干细胞移植治疗恶性血液病对比观察
Author: Feng GAO ; Shuqing FENG ; Mengbo ZHU ; Xiaocong CUI ; Xiaoyu LI ; Xiaomei DU
Publication Type:Journal Article
Keywords: Hematologic neoplasms; Hematopoietic stem cell transplantation; Allogeneic; Haploidy
From: Journal of Leukemia & Lymphoma 2009;18(5):284-286
CountryChina
Language:Chinese
Abstract: Objective To compare the clinical effect, hematopoietic reconstitution, and adverse effects of compatriots HLA in the same period with haploidentical allogeneic hematopoietic stem cell transplantation among relatives for treatment of haematological malignancies. Methods 9 patients of compatriots HLA and 9 patients of haptoidentical allogeneic were recruited. The clinical effect, hematopoietic reconstitution, and transplant-related adverse effects of the observation groups were retrospectively analyzed. Results There was no statistical difference between the clinical effect in two groups, hematopoietic reconstitution, pretreatment-related toxicity and acute and chronic GVHD. The infusion volume of blood products, CMV infection and fungal infection in haploidentical transplant group was higher than that in compatriots HLA group. Conclusion HLA haploidentical family donor transplantation is a good way to increase the source of donor for the treatment of haematological malignancies.