Molecular MRI evaluation of acute thrombus in carotid artery in rabbits
- VernacularTitle:兔颈动脉急性血栓的MRI分子影像学评价
- Author:
Zhihong WANG
;
Huaijun LIU
;
Wenxin WU
;
Yingjin XU
;
Lihong SONG
;
Zejun TIAN
;
Canghai WANG
- Publication Type:Journal Article
- Keywords:
Rabbits;
Carotid arteries;
Thrombosis;
Magnetic resonance imaging;
Molecular imaging
- From:
Chinese Journal of Medical Imaging Technology
2010;26(3):414-417
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the value of a fibrin-targeted contrast agent (EP-2104R) for MR detection of thrombus, and to compare this modality with non-contrast-enhanced (NCE) MRI and Gd-DTPA injection at acute period after thrombus generation. Methods Thrombus was induced with external injury and stasis in 5 rabbits. MRI was performed before and after contrast agent injection at 6.0 h after injury, and the MRI findings were compared with that of histopathologically examinations. Results EP-2104R enhanced MRI accurately detected thrombus, which was superior to both NCE and Gd-DTPA injection (P<0.001). Gd-DTPA injection was not associated with improvement of thrombus detection. Conclusion Being a fibrin-targeted MR contrast agent for in vivo detection of acute thrombus, EP-2104R is superior to NCE MRI and Gd-DTPA injection.
