The Expression and Significance of TSP-1 in Breast Cancer
10.3969/j.issn.0253-9896.2009.10.004
- VernacularTitle:血小板反应蛋白1在乳腺癌中的表达及意义
- Author:
Hongchao WANG
;
Haiping LI
;
Zhonglin FAN
;
Yuntao LI
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
carcinoma;
thrombospondin 1;
RNA;
messenger;
neovascularization;
pathologic reverse transcriptase polymerase chain reaction
- From:
Tianjin Medical Journal
2009;37(10):826-828
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the correlation of thrombospondin-1(TSP-1) expression and angiogenesis and clinical pathologic factors in breast cancer. Methods:Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of TSP-1 mRNA in the primary breast cancer tissues and the tissues set apart 5 cm from the tumor. Im-munohistochemistry was used to detect the expressions of vascular endothelial growth factor (VEGF), c-erbB2, estrogen receptor (ER), progesterone receptor (PR) and microvessel density (MVD). All data were statistically analyzed. Results: The positive rate of TSP-1 was significantly higher in breast cancer than that in tissues set apart 5 cm from tumor (P < 0.05). The expression of TSP-1 was positively correlated with tumor size only (P < 0.05). MVD was lower in TSP-1 positive group than that of negative group (P< 0.05). Conclusion: The MVD was decreased with up-regulation of TSP-1 expression. Thrombospondin-1 may repress the angiogenesis in breast cancer.
