Genetic aberration of FGR and TP73 in peripheral T cell lymphoma not otherwise specified
10.3760/cma.j.issn.1009-9921.2011.05.013
- VernacularTitle:非特指型外周T细胞淋巴瘤FGR和TP73基因改变的研究
- Author:
Yanru WANG
;
Jinfen WANG
;
Jianzhong ZHANG
- Publication Type:Journal Article
- Keywords:
Lymphoma,T-cell,peripheral;
Genes;
In situ hybridization,fluorescence
- From:
Journal of Leukemia & Lymphoma
2011;20(5):296-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic changes of FGR and TP73 in PTCL-NOS, in order to verify the results of our previous a-CGH study and to explore their role on the pathogenesis of PTCL-NOS. Methods A total of 34 cases, of which 19 cases were examined by a-CGH, were investigated by interphasedual-colour FISH using homemade site-specific probes of FGR and TP73 by using a labelling method of nick translation and commercial probe CEP1. Results In general, 7 of 34 (20.6 %) cases of PTCL-NOS showed genetic aberrations, of which 4 cases had changes on both of the loci of FGR and TP73, including 3 cases of amplification and 1 loss of heterozygosity (LOH), 1 case of FGR amplification and other 2 TP73 amplification only. CEP1 amplification was detected in 4 cases (11.8 %), simultaneously associated with FGR/ TP73 gene amplification. Kaplan-Meier survival analysis indicated there was a trend that the group with genetic changes had a poorer prognosis than the group of non-genetic changes, and so as the group of TP73 genetic changes compared with the group of TP73 non-genetic changes, although their was no statistical significance (P >0.05). Conclusion The outcome of this study partially verified the results of a-CGH, and aberration of lymphoma-related genes FGR and TP73, and the amplification of CEP1 may play a significant role in the pathogenesis of PTCL-NOS.
