Isolated Biliary Granulocytic Sarcoma Followed by Acute Myelogeneous Leukemia with Multilineage Dysplasia: A Case Report and Literature Review.
10.3346/jkms.2006.21.3.550
- Author:
Chang Ohk SUNG
1
;
Young Hyeh KO
;
Cheol Keun PARK
;
Kee Taek JANG
;
Jin Seok HEO
Author Information
1. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. yhko@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Sarcoma, Granulocytic;
Leukemia;
Jaundice, Obstructive;
Bile Ducts
- MeSH:
Tomography, X-Ray Computed;
Sarcoma, Granulocytic/*complications/*pathology;
Prognosis;
Male;
Leukemia, Myelocytic, Acute/*diagnosis/*pathology;
Karyotyping;
Humans;
Cell Lineage;
Bile Ducts/metabolism/pathology;
Bile Duct Neoplasms/*complications/*pathology;
Adult
- From:Journal of Korean Medical Science
2006;21(3):550-554
- CountryRepublic of Korea
- Language:English
-
Abstract:
Granulocytic sarcoma is a rare extramedullary tumor composed of myeloid progenitor cells. Primary involvement of the biliary tract without evidence of leukemia is exceedingly rare. Here, we report an isolated biliary granulocytic sarcoma in a 30-yr-old man who presented with jaundice, fever, and chill without any evidence of leukemia. However, five months after the diagnosis, he developed acute myelogenous leukemia with multilineage dysplasia and chromosomal abnormality. A rare possibility of biliary granulocytic sarcoma should be considered as a differential diagnosis in patients with obstructive jaundice. A histologic evaluation by aggressive diagnostic intervention is important and may improve prognosis.
