Risk factors of the prognosis of severe fever with thrombocytopenia syndrome infected by a novel bunyavirus: a retrospective analysis study
10.3760/cma.j.issn.1671-0282.2015.04.009
- VernacularTitle:新型布尼亚病毒感染致发热伴血小板减少综合征预后相关性分析
- Author:
Shuyu JIANG
;
Jingjun LV
;
Jie WEI
;
Shengnan SUN
;
Rui WANG
;
Weize YANG
;
Dan TIAN
- Publication Type:Journal Article
- Keywords:
Novel bunyavirus;
Severe fever with thrombocytopenia syndrome;
Risk factors;
Liver function;
Coagulation;
Retrospective analysis
- From:
Chinese Journal of Emergency Medicine
2015;24(4):380-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate risk factors of the prognosis of patients with severe fever with thrombocytopenia syndrome (SFTS).Methods From May 2012 to July 2014,17 cases of severe fever with thrombocytopenia syndrome in Renmin Hospital of Wuhan University were treated.Clinical data including history of epidemiology,clinical manifestations,complications,physical examination and laboratory test results on admission and the third day after admission were retrospectively analyzed and compared with the death group and recovery group by application of Spearman correlation analysis.Results Elderly male patients with neuropsychiatric symptoms,or abnormal liver function,or abnormal blood clotting function had higher risk of the poor prognosis.In SFTS patients,AST,ALT was significantly increased,AST 539 U/L (229.73,545.4) U/L (r =0.597,P =0.015) was a risk factor affecting prognosis.Elevated blood ammonia indicated serious liver dysfunction and neurological dysfunction which were manifested as irritability,delirium,and trembling limbs.In SFTS patients,platelets were significantly decreased accompanied with mouth ulcers / bleeding gums,gastrointestinal bleeding.PLT 24.88 × 10 9/L-1 (12.75,35.00) ×10 9/L-1 (r=0.557,P=0.005) or APTT 86.06 s (66.88,114.18) (r=0.798,P=0.001) or D-dimmer 9.79 mg / L (4.09,16.51) mg/L (r =0.597,P =0.015) are risk factors affecting poor prognosis.Conclusions On the third days after admission,AST,WBC,PLT,APTT,Ddimmer are risk factors for prognosis of patients with severe fever with thrombocytopenia syndrome infected by a novel bunyavirus.
