Prospective study of risk factors in ventilator-associated pneumonia in mechanically ventilated patients in ICU

VernacularTitle:重症医学科呼吸机相关性肺炎危险因素的前瞻性研究
Author: Jun YANG ; Haiyan WANG ; Hui LIANG ; Jingjing XI ; Rui CHENG
Publication Type:Journal Article
Keywords: Ventilator-associated pneumonia; Risk factor; Mechanical ventilation; Prospective study
From: Chinese Journal of Emergency Medicine 2014;23(11):1239-1243
CountryChina
Language:Chinese
Abstract: Objective To analysis the risk factors in ventilator-associated pneumonia (VAP) in mechanically ventilated patients.Methods Seventy-eight adult inpatients on mechanical ventilation (MV) through oral endotracheal intubation were studied prospectively by observation between June,2007 and May,2010.Clinical associated factors including patients'predisposition related,medical personnel or device related and nutritional state related factors,etc.were recorded and analyzed.Results In 78 ventilated patients,the incidence of VAP was 23.1％,the fatality rate was 22.2％.Preventive antibiotic treatment (OR=6.038; 95％ CI:1.319-27.641; P =0.021),applying glucocorticoid (OR =5.385; 95％ CI:1.191-24.346; P =0.029) and prealbumin (PA) ≤ 69.7 mg/L (OR =0.975; 95％ CI:0.956-0.995 ; P =0.013) were risk factors in VAP.Conclusions The risk factors in VAP were PA ≤ 69.7mg/L,preventive antibiotic treatment and employment of glucocorticoid.