New synthesis method of chlorpropamid
- Author:
Chau Dinh Phan
- Publication Type:Journal Article
- Keywords:
chlorpropamid
- MeSH:
Chlorpropamide;
Methods
- From:Pharmaceutical Journal
2002;320(12):12-14
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The chlorpropamid (1) is an antidiabetic drug synthetized from chlorobenzene (2) in five steps through intermediates p-clorobenzenesulfonyl chloride (3), calcium p-chlorobenzene sulfonyl cyanamide (6), p-clorobenzenesulfonyl cyanamide (7), p-clorobenzenesulfonyl urea (8) and then the compound 8 was condensated with n-propylamine. The product have melting point, Rf, IR spectral data that suitable with to the chlopropamid extracted from Novopropamid tablet of Canada.
