Clinical study of the influence of continuous hemofiltration on gastrointestinal dysfunction of the patients with intra-abdominal hypertension
10.3760/cma.j.issn.1671-0282.2014.10.017
- VernacularTitle:持续性血液净化治疗对腹腔内高压患者的胃肠功能障碍的影响
- Author:
Xin XU
;
Man HUANG
;
Pengfei WANG
;
Qiuping XU
- Publication Type:Journal Article
- Keywords:
Hemofiltration;
Intra-abdominal hypertension;
Gastrointestinal dysfunction
- From:
Chinese Journal of Emergency Medicine
2014;23(10):1138-1142
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of continuous hemofihration on gastrointestinal dysfunction for treating patients with intra-abdominal hypertension.Methods A total of 37 patients were divided into two groups randomly (random number),namely control group (n =17) and continuous blood filtration (CBF) group (n =20).The patients of control group were treated with routine treatment,and the patients of CBF group were given CBF for 72 hours in addition to the routine treatment.The intra-abdominal pressure (IAP),gastrointestinal (GI) symptoms,and SOFA score were documented at 0 hour,24 hours,72 hours and 7 days after treatment.Results The MAP of patients in the CBF group was not significantly changed (P =0.218),while the IAP was decreased significantly (P =0.001) and the abdominal perfusion pressure (APP) increased significantly after CBF (P =0.036).Compared with the control group,there were more than 2 GI symptoms markedly relieved after CBF for 24 hours (P =0.049).The SOFA score of CBF group decreased significantly (P =0.037).There were no differences in 28-day and 60-day mortality between two groups.Conclusions The CBF can decrease IAP,increase APP,improve splanchnic blood circulation,and ameliorate gastrointestinal dysfunction.But CBF does not reduce the mortality in comparison with routine treatment.