Advance research of p53 gene therapy combination with transcatheter arterial chemoembolization for hepatocellular carcinoma
10.3760/cma.j.issn.1673-4203.2015.04.016
- VernacularTitle:腺病毒p53联合经导管肝动脉化疗栓塞术治疗原发性肝癌研究进展
- Author:
Chaoqian ZHU
;
Jun YIN
- Publication Type:Journal Article
- Keywords:
Adenoviruses,human;
Genes,p53;
Liver neoplasms;
Transcatheter arterial chemoembolization
- From:
International Journal of Surgery
2015;42(4):260-264
- CountryChina
- Language:Chinese
-
Abstract:
About the malignant tumor in China,the hepatocellular carcinoma mortality is second only to lung cancer and serious threat to the life and health of the masses.Furthermore,because most patients has been in advanced cancer during medical treatment,so had lost the chance of one-stage surgical resection.However,the sensitivity of hepatocellular carcinoma to chemotherapy,radiotherapy and other treatments are poor.Transcatheter arterial chemoembolization is the main method of the treatment for patients those have lost the chance of operation,though the clinical effect is significant,the inadequate is also presence,such as tumor necrosis,incompletely clear,residual tumor nidus and the damage of the immune function after operation.Recombinant adenovirus p53 gene can validly infect tumor cells,transcription and expression of p53 protein,it also regulate the expression of related genes inhibiting tumor cell growth and induce cell apoptosis directly or indirectly.It is increasingly highly attention that recombincanting rAd-p53 with transcatheter arterial chemoembolization(TACE) to treat hepatocellular carcinoma.In order to evaluate the clinical value and promising future,we will make a brief summary for the research progress in this area in recent years.
