Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a Meta-analysis

VernacularTitle:胆道结石并发肝内胆管癌风险的Meta分析
Author: Zhenghai ZHU ; Hao CAI ; Yanyan GU ; Wanwen ZHAO ; Weidong HU ; Chaobo CHEN
Publication Type:Journal Article
Keywords: Intrahepatic cholangiocarcinoma; Gallstones; Choledocholithiasis; Cholecystolithiasis; Risk factors
From: International Journal of Surgery 2015;42(2):97-101
CountryChina
Language:Chinese
Abstract: Objective To clarify the association of pre-existing choledocholithiasis or cholecystolithiasis and the development of intrahepatic cholangiocarcinoma(ICC).Methods A computerized literature search was performed in Pubmed,EmBase and CBM.Cohort and case control studies on the risk of choledocholithiasis or cholecystolithiasis developing ICC was included.Meta-analysis was performed using STATA version 12.0.Either a fix or random effect model was used according to heterogeneity among studies.Egger's test was performed to assess publication bias.Results A total of 6 case control studies fulfilled our inclusion criteria including 123,713 patients,4,753 for ICC and 118,960 for tumor free controls.Bile duct stone contributed to the development of ICC (OR:15.64,95％ CI 9.33-26.23).Apart from hepatolithiasis,there was still a high risk of ICC development for choledocholithiasis (OR:11.05,95 ％ CI:4.02 ～ 30.37).Cholecystolithiasis is also a risk factor for ICC (OR:2.35,95 ％ CI:1.28 ～ 4.31).Conclusion Both choledocholithiasis and cholecystolithiasis are important prognostic factors for ICC.