Association of ATBF1 and the growth and progression of malignant tumor

VernacularTitle:AT模体结合因子1与恶性肿瘤发生及发展相关性的研究进展
Author: Zhiqun LIN ; Fei CHEN ; Zonghai HUANG
Publication Type:Journal Article
Keywords: AT motif binding factor1; Malignant tumor; Cancer suppressor gene
From: International Journal of Surgery 2015;42(1):56-60
CountryChina
Language:Chinese
Abstract: AT motif binding factor 1 (ATBF1) gene,is a new tumor suppressor gene,and one of its expression variants by alternative splicing,known as ATBF1-A,can bind to the enhancer AT-rich element of alpha fetoprotein (AFP) and down-regulate the transcription of AFP,which may suppress the development and induce the apoptpsis of some carcinoma cells.In this review,we attempted to analysis the pathway of ATBF1 behaves with other factors and its multiple biological functions;ATBF1 function as a suppressor gene,it was illustrated for the influence on the growth and invasion of breast,prostate or gastric cancer.We also discussed the application of the ATBF1 level function as a cancer predictor,and forecasted the significance to apply ATBF1 for the therapy of cancer.