Research progress of patient-derived xenograft model
10.3760/cma.j.issn.1673-4203.2015.01.018
- VernacularTitle:人源肿瘤异种移植模型的研究进展
- Author:
Chenchen LIU
;
Dongwang YAN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Transplantation,heterologous;
Xenograft model antitumor assays;
Individualized treatment
- From:
International Journal of Surgery
2015;42(1):50-52
- CountryChina
- Language:Chinese
-
Abstract:
Tumor cell line culture technologies emerged as a strong impetus to the development of tumor biology research.However,cell line tumor model presented limited predictive value and instable properties in the clinical translational research of new cancer therapies.Recently Patient-derived Xenograft Model (PDX) has aroused researcher's attention and been widely applied to new cancer therapy research.This new model could highly retain the stroma heterogeneity、histological characteristics and molecular diversity of the original tumor,and is expected to bring new breakthroughs in individualized treatment of tumor patients.
