Research progress of microRNA-21 in chemoradiotherapy of glioma
10.3760/cma.j.issn.1673-4203.2014.11.017
- VernacularTitle:microRNA-21对于神经胶质瘤辅助治疗的研究进展
- Author:
Min WEI
;
Lun DONG
;
Yuping LI
;
Hengzhu ZHANG
- Publication Type:Journal Article
- Keywords:
microRNA-21;
Glioma;
Chemoradiotherapy resistance;
Brain neoplasms;
Review
- From:
International Journal of Surgery
2014;41(11):777-780
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is an important cause of death in adults and children among the most common neural malignancies,with high morbidity and mortality in primary brain tumors.Despite advances in radiation and chemotherapy following surgical resection of the tumor,the median survival time of glioma remains poor.The effects of miR-21expression on tumor growth and invasion via regulating the pathways in human glioma cells,which regulate the expression of some small molecule.This review is mainly focused on the discovery of the correlation between microRNA-21 (miR-21) and glioma and the important role in the resistance of cancer cells to radiation and chemotherapeutic agents.
