Correlation between the expression of periostin and Epithelial-mesenchymal transition markers in colorectal cancer
10.3760/cma.j.issn.1673-4203.2014.11.010
- VernacularTitle:骨膜蛋白与上皮-间质转化标志物在结直肠癌中表达相关性的研究
- Author:
Leilei YAN
;
Jing YAO
;
Xuebing YAN
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
Periostin;
Epithelial-mesenchymal transition;
Colorectal neoplasms;
Cadherins;
Tissues
- From:
International Journal of Surgery
2014;41(11):750-754
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the Periostin and Epithelial-Mesenchymal Transition(EMT) markers(E-cadheirn and N-cadheirn) in colorectal cancer(CRC),and analyze the relationship between the expression of Periostin and clinicopathological parameters.Methods The expression of Periostin,Ecadheirn and N-cadheirn in 106 cases with primary CRC tumors and corresponding normal tissues were detected by Immunohistoehemistry and the results were analyzed.Results The expression of Periostin,E-cadheirn and N-cad-heirn in tumors were significantly high expression than those in corresponding normal tissues(62/106 vs 21/106,x2 =34.027,P ＜ 0.05 ;43/106 vs 89/106,x2 =42.480,P ＜ 0.05 ; 66/106 vs 19/106,x2 =43.382,P ＜ 0.05).The expression of Periostin in tumors was associated significantly with tumor differentiation,tumor invasion,lymph node metastasis and distance metastasis (x2 =7.752,P =0.007; x2 =5.008,P =0.031 ; x2 =10.227,P =0.002;x2 =8.001,P =0.006).It was negatively correlated with E-cadherin expression (r =-0.435,P ＜ 0.001),but positively correlated with N-cadherin expression (r =0.213,P =0.028).Conclusion Periostin may promote the occurrence and development of CRC by participating in EMT program.
