Preparation and characterization of self-assembled thiolated chitosan derivatives and gold nanoparticles
10.3760/cma.j.issn.1673-4181.2015.02.001
- VernacularTitle:壳聚糖基金纳米棒自组装纳米球的制备与表征
- Author:
Ruihua KOU
;
Ruiping DUAN
;
Yingjie LIU
;
Man GUAN
;
Jingjie WANG
;
Qiqing ZHANG
- Publication Type:Journal Article
- Keywords:
Chitosan nanoparticles;
Gold nanorods;
Molecular detection;
Surface-enhanced Raman scattering
- From:
International Journal of Biomedical Engineering
2015;38(2):65-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare self-assembled thiolated chitosan derivatives gold nanoparticles (CS-GNRs) and carry out the feature tests.Methods CS-GNRs was prepared by chitosan derivatives and GNRs through strong metal sulfur chemical bond between thiols and gold on GNRs surface.Morphology features was tested by transmission electron microscope,dynamic light scattering was adopted to observe the size of nanoparticles.Ultraviolet-visible spectrophotometer was used to detect the optical properties and the property change.Meanwhile,the surface-enhanced Raman scattering (SERS) activity of CS-GNRs was investigated by using crystal violet (CV) as a probe molecular.Results CS-GNRs were in good shape,uniform particle size and good dispersion.The SERS of CV was enhanced,and the enhancement factor of CV adsorbed on CS-GNRs was up to 2×103.Conclusions The nanoparticles have potential application in molecular detection and Raman spectra detection.
