Comparative study of three biodegradable films for protein drug carrier
10.3760/cma.j.issn.1673-4181.2014.06.004
- VernacularTitle:三种用于蛋白类药物载体的可降解膜的比较研究
- Author:
Ting XIA
;
Shuyi LI
;
Hongfan SUN
;
Mei YU
- Publication Type:Journal Article
- Keywords:
Gelatin;
Chitosan oligosaccharides;
Chitosan;
Bovine serum albumin;
Film
- From:
International Journal of Biomedical Engineering
2014;37(6):332-336
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare three kinds of biodegradable film materials used for protein drug carrier,and compare their degradation and drug release behavior.Methods Three different biodegradable and controlled release films,gelatin,chitosan oligosaccharides and crosslinked chitosan oligosaccharides films were prepared.Protein release behavior was determined by the Bradford.At the same time,degradation rate and swelling rate were tested,and the biocompatibility of film was investigated by MTT assay.Results The release time of crosslinked chitosan oligosaccharides film was 168 h,which was longer than that of chitosan oligosaccharides film,and different in different solution.The degradation rate and the swelling rate of crosslinked chitosan oligosaccharides was 60％ (360 h) and 110.45％,respectively,while the chitosan oligosaccharides membrane was 80％ (360 h) and 113.03％.The MTI assay revealed that the crosslinked chitosan oligosaccharides film had better biocompatibility.Conclusions By comparing different properties,the crosslinked chitosan oligosaccharides film is the best choice for protein drug carrier.
