Research progress of TKTL1 in malignant neoplasms
10.3760/cma.j.issn.1006-9801.2015.05.017
- VernacularTitle:TKTL1在恶性肿瘤中的研究进展
- Author:
Huan LU
- Publication Type:Journal Article
- Keywords:
TKTL1;
Malignant neoplasms;
Transketolase;
Biomarker
- From:
Cancer Research and Clinic
2015;27(5):352-355
- CountryChina
- Language:Chinese
-
Abstract:
Up to now,one transketolase (TKT) and two transketolase-like genes (TKTL1 and TKTL2) have been identified in the human genome.People have conducted a series of basic and clinical researches of TKTL1 in malignant neoplasms since Coy found TKTL1 has a high expression of protein and gene levels in the malignant tumors in 2005.Although the biochemical and functional mechanism have not been clarified clearly,a positive role of TKTL1 in promoting tumorigenesis and tumor progression has been proved.
