Research progress of application of immunotherapy by chimeric antigen receptor-engineered T cells
10.3760/cma.j.issn.1006-9801.2015.02.022
- VernacularTitle:嵌合抗原受体修饰的T细胞免疫治疗研究进展
- Author:
Wei LI
;
Huijie YU
- Publication Type:Journal Article
- Keywords:
Adoptive immunotherapy;
Chimeric antigen receptor;
Cancer immunotherapy
- From:
Cancer Research and Clinic
2015;27(2):139-141
- CountryChina
- Language:Chinese
-
Abstract:
The technique of chimeric antigen receptor-engineered T cells (CAR-T) is combined single chain antibody and T-cell activation modification and has specific and durable killing effect on tumors.It had achieved stunning results on clinical trials of B lymphocytic leukemias,B lymphomas and solid tumors.Meanwhile it also had potential risk on the off target effects,cytokine release syndrome,graft versus host disease and so on.This paper briefly reviews the principal of CAR-T cellular mechanism,advantages and clinical applications.
