Research progress of Brachyury gene and protein in tumors
10.3760/cma.j.issn.1006-9801.2015.02.020
- VernacularTitle:Brachyury基因及蛋白在肿瘤中的研究进展
- Author:
Yanjun FENG
- Publication Type:Journal Article
- Keywords:
Brachyury gene;
Brachyury protein;
Epithelial-mesenchymal transition;
Cancer stem cells;
Cell cycle
- From:
Cancer Research and Clinic
2015;27(2):132-135
- CountryChina
- Language:Chinese
-
Abstract:
The Brachyury gene (T-gene) and its coded product Brachyury potein which belong to T-box transcription factor family,are critical in the development of mesoderm and formation of notochord.Recent researches show accumulating evidences of its important role in tumorigenesis and cancer progression.The mechanisms involved may include epithelial-mesenchymal transition,cancer stem cells,cell cycles,senescence and resistance of conventional radiotherapy or chemotherapy.
