Evaluation of PL-11 in short-term antiplatelet therapy monitoring
10.3760/cma.j.issn.1009-9158.2014.12.021
- VernacularTitle:评价血小板分析仪PL-11监测正常人短期抗血小板治疗
- Author:
Jie GUAN
;
Junwei REN
;
Yuan ZHU
;
Li LI
;
Zulan LI
;
Xinli DENG
;
Yulong CONG
- Publication Type:Journal Article
- Keywords:
Platelet function tests;
Platelet count;
Thrombelastography
- From:
Chinese Journal of Laboratory Medicine
2014;37(12):954-957
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate a new platelet function analyzer PL-11 with three major platelet function methods.Methods A randomized controlled trial was adopted.Totally 20 healthy young students from People's Liberation Army Medical School were enrolled in the study during July and August in 2013.Subjects were treated with aspirin or clopidogrel and the platelet function was measured by using of PL-11,as well as light transmittance aggregometry (LTA),VerifyNow and thromboelastography (TEG).Results When monitor aspirin response,correlations between arachidonic acid (AA) induced PL-11 and other methods were:LTA,0.614; VerifyNow,0.829; TEG,0.697,respectively.Biases between AA induced PL-1 1 and LTA were 1.94％ at baseline and 24.02％ during aspirin treatment.Cut-off value of aspirin response tested with AA induced PL-11 was 33.3％.When monitor clopidogrel response,correlations between adenosine piphosphate (ADP) induced PL-11 and other methods were:LTA,0.767; VerifyNow,0.851; TEG,0.608.Biases between ADP induced PL-11 and LTA were 3.01％ at baseline and 6.56％ during clopidogrel therapy.Cut-off value of clopidogrel response tested with ADP induced PL-1 1 was 66％.Conclusion Results of different platelet function testing methods were not equally effective.PL-11 has a high capability when monitoring short aspirin or clopidogrel response.
