Effects of leukocyte-depleted allogeneic blood transfusion on perioperative cellular immunity in children
- VernacularTitle:滤除白细胞异体血对围术期患儿细胞免疫功能的影响
- Author:
Zhun XING
;
Qiushi WANG
;
Yanni DIAO
;
Qiaoni YANG
;
Xiaojing DUAN
;
Simeng WU
;
Lingxin MENG
- Publication Type:Journal Article
- Keywords:
leukapheresis;
blood transfusion;
immunity,cellular;
child
- From:
Chinese Journal of Anesthesiology
2014;34(z1):48-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of leukocyte-depleted allogeneic blood transfusion on perioperative cellular immunity in children.Methods Three hundred and fifty-nine ASA Ⅰ or Ⅱ children (aged 3 months-14 years and weighing 5-74 kg) requiring allogeneic blood transfusion during operation were randomly divided into two groups:163 children receiving normal allogeneic blood transfusion (control group,group C) and 196 children receiving leukocyte-depleted allogeneic blood transfusion (group D).Blood samples were collected from the peripheral vein before blood transfusion,and 2 and 6 days after blood transfusion for determination of the levels of CD3+,CD4+,CD8 +,and CD56+ by flow cytometry.CD4+ /CD8+ ratio was calculated.The volume of allogeneic blood transfusion during operation,the duration of operation,postoperative drainage,antibiotic administration,hospital stay and the incidence of postoperative infection were recorded.Rssults The levels of CD3+,CD4+,CD56+ and CD4+/CD8+ ratio significantly increased at 6 days after blood transfusion while the duration of postoperative drainage,postoperative antibiotic administration,hospital stay and the incidence of postoperative infection significantly decreased in group D compared with group C.Conclusion Leukocyte-depleted allogeneic blood transfusion is helpful in improving the postoperative cellular immunity in children.
