Association between prostate histologic inflammation classification and prostate cancer in needle biopsy specimens with serum PSA under 20 μg/L
10.3760/cma.j.issn.1000-6702.2015.04.012
- VernacularTitle:血清前列腺特异性抗原小于20μg/L患者前列腺穿刺标本中炎症分级与前列腺癌的相关性分析
- Author:
Dalei ZHANG
;
Lei HE
;
Wei ZHANG
;
Ming LIU
;
Ben WAN
;
Jianye WANG
;
Bin JIN
- Publication Type:Journal Article
- Keywords:
Prostatitis;
Inflammation classification;
Prostatic neoplasms;
Biopsy
- From:
Chinese Journal of Urology
2015;36(4):290-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between prostate histologic inflammation classification and prostate cancer (PCa) in needle biopsy specimens with serum prostatic specific antigen (PSA) under 20 μg/L.Methods The clinical records of patients who underwent prostate biopsy were retrospectively analyzed in Beijing Hospital Urological Department from January 2011 to December 2013.The patients underwent prostate biopsy because of PSA raised and without pelvic radiotherapy.The needle biopsy specimen was evaluated by the pathohistologic criteria of location,extent and grade classification of prostate inflammation.Results PCa was detected in 84 (37.2％) biopsies and benign prostatic disease (BPD) in 142 (62.8％) biopsies.There were significant differences between PCa and BPD in inflammation classification (location:P＜0.001,extent:P＜0.001,grade:P＜0.001).On multivariable Logistic regression analysis,both location and extent classification of chronic histologic prostatitis were found tobe significantly associated with a lower risk of PCa in biopsy (location:P =0.001,OR =0.114,95％ CI 0.032-0.405 ; extent:P =0.021,OR =0.232,95％ CI 0.067-0.804).There was no relationship between grade classification and PCa (P=0.223,OR=1.805,95％CI 0.698-4.667).Under the evaluation of location and extent classification,it could differentiate PCa with BPD in biopsy with a sensitivity,specificity,positive predictive value and negative predictive value of 91.7％,50.7％,52.4％,91.1％,respectively.Conclusion The location and extent classification of chronic prostatitis is found to be associated with a lower risk of PCa independently.
