The degree and distribution of hub regions of the brain structural networks in schizophrenia
10.3760/cma.j.issn.1674-6554.2014.12.007
- VernacularTitle:精神分裂症患者脑结构网络节点度及其核心节点分布属性研究
- Author:
Jianhuai CHEN
;
Zhijian YAO
;
Jiaolong QIN
;
Hao TANG
;
Rui YAN
;
Lingling HUA
;
Qing LU
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Diffusion Tensor Imaging;
Brain structural network;
Node degree;
Hubs
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;23(12):1079-1082
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the differences of the degree and distribution of hub regions of the brain structural networks between the schizophrenia and healthy and then analysis the importance of brain regions in the information transmission in across the whole brain.Methods The diffusion tensor imaging data were obtained from 22 schizophrenia patients and 24 healthy controls.The whole cerebral cortex was parcellated into 90 regions by the anatonical label map.Tractography was performed in the whole cerebral cortex of each subject to reconstruct white matter tracts of the brain using the fiber assignment by continuous tracking (FACT) algorithm.And then the brain structural binary networks were constructed using the complex network theory.The average degree of the network and the degree of the nodes in the network between the brain structural networks of both groups were examined by two sample t-tests.Results The average degree of the brain structural network in the patient group (7.82±0.56) decreased significantly when compared with the control group (8.17 ±0.56; P=0.04).The degree of the nodes in the brain structural network of the patient group (the left hippocampus:11.41 ± 1.84; the left parahippocampal gyrus:6.41± 1.33 ; the left calcarine fissure:11.50±2.97 ; the left fusiform gyrus:8.27± 1.83) decreased significantly when compared with the control group (14.43±2.26; 8.54±2.15; 14.79±2.80; 10.25± 1.36; all P＜0.01,survived critical FDR threshold for multiple comparisons).And the distribution of the hub regions in the temporal and occipital lobes of the patient group was difference from that of the control group.Conclusion The importance of the hippocampus and the brain regions in the occipital lobe is decrease for the information transmission across the whole brain.The damage of the topological properties of these brain regions maybe related to the disorder of the transmission and integration of information in the brain of the schizophrenia.
