Serotonin system and post-stroke depression
10.3760/cma.j.issn.1674-6554.2015.04.023
- VernacularTitle:5-羟色胺系统与卒中后抑郁
- Author:
Feng MEI
;
Shuyin SUN
;
Zuoji ZHANG
;
Zhongrui YAN
- Publication Type:Journal Article
- Keywords:
Serotonin;
Post stroke depression;
Gene polymorphism
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(4):360-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the 5-hydroxytryptamine (5-HT) on the occurrence,development of post-stroke depression (PSD).Methods The literatures on the relationship between 5-HT and PSD were selected from databases such as Wanfang Data,CNKI and PubMed before in 2010-2014.According to absorption and exclusion criteria of the literature,collect literatures,and summary,induce and analyze on them.Results Search 258 literatures and accept 44 literatures accorded with the criteria,including the relationship between 5-HT and PSD,the relationship between 5-hydroxytryptamine receptor (5-HTR) gene polymorphism and PSD,the relationship between 5-hydroxytryptamine transporter linked promoter region (5-HTTLPR) and PSD,and the treatment of selective serotonin reuptake inhibitors (SSRIs) in PSD.Conclusion Reduced levels of 5-HT lead to the occurrence of PSD,and they had a negative correlation;5-HTR 1 A,5-HTR2A are related genes of PSD;S allele and S/S genotype is susceptible factors of PSD,while the L allele is the protective factors of PSD;SSRIs can increase the level of 5-HT in the synaptic gap so as to improve the depressive symptoms of PSD.In the future,it is necessary to increase the sample size to confirm the relationship between 5-HT and PSD,and combine with other factors to explore the relationship between them.
