Study on response inhibition and working memory in alcohol dependent patients

VernacularTitle:酒依赖患者的反应抑制和工作记忆研究
Author: Shanshan HONG ; Bojun HAN ; Kai JI ; Chunyan DU ; Qingguang WANG ; Dinghua LIU
Publication Type:Journal Article
Keywords: Alcohol dependence; Response inhibition; Working memory; Neuropsychological test
From: Chinese Journal of Behavioral Medicine and Brain Science 2014;23(9):808-810
CountryChina
Language:Chinese
Abstract: Objective To detect the impairment of response inhibition and working memory in patients with alcohol dependence.Methods A total of forty-eight alcohol dependent patients and fifty age,gender,IQ,education matched controls were recruited.Neuropsychological tests were applied to measure the differences of response inhibition and working memory between the two groups.Results In the response inhibition task,the patient group had more commission errors ((7.02± 3.48) vs (3.45± 1.52)) and longer reaction time ((605.45 ± 142.56)ms vs (435.72±51.18)ms) compared to the control group (t=6.534,P=0.000; t=7.781,P=0.000).In the spacial working memory task,the patient group also had more commission errors ((4.58± 3.45) vs (0.43± 0.88)) and longer reaction time((10566.16±2455.61) ms vs (9185.44±2677.52) ms) than control (t=8.085,P =0.000; t=2.657,P=0.009).Conclusion There are significant deficiencies in response inhibition and working memory in patients with alcohol dependence.