The serum concentrations of brain derived neurotrophic factor and its G196A polymorphism in amphetamine induced-psychosis inpatients
10.3760/cma.j.issn.1674-6554.2015.03.011
- VernacularTitle:苯丙胺所致精神障碍患者血清脑源性神经营养因子水平及其基因G196A多态性研究
- Author:
Xianfei JIANG
;
Feng HOU
;
Niansheng WANG
;
Zhonghua SU
;
Wei HAO
- Publication Type:Journal Article
- Keywords:
Methamphetamine abuse;
Brain-derived neurotrophic factor;
Gene polymorphism
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(3):230-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the serum concentrations of brain derived neurotrophicfactor (BDNF) and its G196A polymorphism in the amphetamine induced-psychosis inpatients.Methods The cross-sectional study included 233 amphetamine abuses and 110 healthy participants who served as controls.The serum concentration of BDNF was measured by sandwich ELISA,and the genotype of BDNF G196A polymorphism was determined used polymerase chain reaction (PCR) techniques.The data were analyzed using SPSS 12.0 statistics software.Results The serum concentration of BDNF in case group((205.81±75.36) pg/ml) were significantly higher than that in control group((95.04±31.63) pg/ml;t=15.02,P＜0.01).There was no significant difference about the BDNF serum concentrations between the inpatients with the amphetamine induced psychosis and the inpatients with the amphetamine abuse (P＞0.05).The BDNF serum concentration showed no significant difference in the genotype distributions and allele frequencies (P＞0.05).The genotype distributions and allele frequencies of BDNF G196A showed no significant difference among three groups(P＞0.05).Conclusion The BDNF serum concentration is correlated with methamphetamine abuse,while the BDNF G196A gene polymorphism may not be associated.
