The relationship between the serum ACA, VEGF concentration and cognitive impairment in patients with cerebral infarction
10.3760/cma.j.issn.1674-6554.2015.02.016
- VernacularTitle:脑梗死患者血清抗心磷脂抗体和血管内皮生长因子水平与卒中后认知障碍的关系
- Author:
Xianbo ZHUANG
;
Guangjun XU
;
Weifei WANG
;
Guangzhen SHAN
;
Xiafeng YANG
- Publication Type:Journal Article
- Keywords:
Ischemic stroke;
Cognitive impairment;
Anticardiolipin antibody;
Vascular endothelial grow factor
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(2):152-154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the serum anticardiolipin antibody (ACA),vascular endothelial grow factor (VEGF) concentration and cognitive impairment in patients with ischemic stroke.Methods Totally 128 cases with acute ischemic stroke were admmitted in stroke unit ward of our hospital during June 2014 to December 2014.According to the score of Montreal cognitive assessnent (MoCA),128 patients with ischemic stroke were divided into groups A (53 cases with cognitive impairment) and group B (75 cases without cognitive impairment).The concentrations of serum ACA,VEGF were quantitatively determinated by ELISA.The differences of serum ACA,VEGF concentrations were compared between the two groups.Results Compared with normal cognitive function group,the cognitive impairment patients had significantly higher ACA concentration ((0.86±0.16) mg/L vs (0.52±0.08) mg/L,P＜0.01),and lower VEGF concentration ((197.60±7.48) pg/ml vs (205.80±8.52) pg/ml,P＜0.05).Logistic regression revealed that ACA and VEGF were independent effect factors for cognitive impairment (ACA:B =2.841,OR =0.33,95 ％ CI =0.118-0.926,P=0.025.V EGF:B =-1.674,OR =4.99,95％ CI =1.688-4.741,P=0.034).Conclusion ACA and VEGF may play an important role in cognitive impairment after ischemic stroke.
