Association study between catechol-O-methyltransferase Val158Met polymorphism and the memory function of schizophrenia treated with Aripiprazole
10.3760/cma.j.issn.1674-6554.2015.01.009
- VernacularTitle:儿茶酚氧位甲基转移酶基因多态性与精神分裂症患者记忆功能及阿立哌唑疗效的关联研究
- Author:
Qiang FAN
;
Shugui GAO
;
Guangxue LI
;
Jia CHENG
;
Yongming XU
;
Shuguang XIE
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Catechol-O-methyltransferase;
Aripiprazole;
Memory function
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(1):31-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between catechol-O-methyltransferase (COMT) Val158Met polymorphism and the memery function of schizophrenia treated with Aripiprazole.Methods Schizophrenic patients were diagnosed in according to Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV).A total of 78 Chinese Han subjects were involved in this study.The polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was used to identify COMT genotypes.The Chinese revised version of Wechsler Memory Scale (WMS-RC) was used twice to evaluate the memory function of patients treated with Aripiprazole alone before and after drug treatment for 8 weeks.ANOVA,rank sum test and t-test were used to statistical analysis.Results There was statistical difference of cumulative memory among the three groups (F=12.371,P=0.002),and Met/Met genotype showed much poorer cumulative memory than Val/Met and Val/Val genotypes (Z=-3.168,-2.641 ; P=0.002,0.008,respectively) Memory function was significantly improved after patients been treated with Aripiprazole except the associative memory(P＜0.05).Met/Met genotype showed more improvement of cumulative memory than other genotypes after Aripiprazole treatment (t=4.203,P＜0.01 ; t=3.024,P ＜0.01,respectively).Conclusions There may be a relationship between COMT Val158Met polymorphism and the memory function of schizophrenia in Aripiprazole treatment.Met/Met genotype of schizophrenia showed worst cumulative memory but best responsiveness in Aripiprazole treatment.
