The combined analysis of susceptibility weighted imaging and proton spectroscopy sequence by high field magnetic resonance in the first-episode depression patients
10.3760/cma.j.issn.1674-6554.2014.10.011
- VernacularTitle:磁共振质子波谱和磁敏感对首发单相抑郁症患者海马组织代谢及回流静脉的联合分析
- Author:
Liang ZHAO
;
Yuefeng LI
;
Dongqing WANG
;
Ying ZHU
;
Yan ZHU
;
Ruigen YIN
- Publication Type:Journal Article
- Keywords:
Susceptibility weighted imaging;
Proton magnetic resonance spectroscopy;
Hippocampus;
Depressive disorder
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;23(10):901-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective Combined with susceptibility weighted imaging (SWI) and proton magnetic resonance spectroscopy (1H-MRS) to study the hippocampus in the first-episode depression patients for exploring the causal relationship.Methods 20 first-episode depression patients and 20 healthy volunteers underwent SWI scanning and hippocampal 1H-MRS image,analysis and comparison the changes between the venous system and metabolism of two groups.Results Proton spectroscopy analysis showed that compared with the control group,bilateral hippocampal NAA/Cr(left hippocampus:depression group 0.95±0.77,control group 1.78±0.82; right hippocampus:depression group 1.12±0.74,control group 1.91 ± 0.80) and Cho/Cr (left hippocampus:depression group 1.08±0.83,control group 1.75±0.73 ; right hippocampus:depression group 0.91±0.68,control group 1.95 ±0.74) in the depression group was significantly lower,the difference was significant(NAA/Cr:t value in left and right were -3.14,-3.49,P＜0.05; Cho/Cr:t value in left and right were-3.25,-3.19,P＜0.05),however MI/Cr had no obvious changes (t value in left and right were 1.24,-1.27,P＞0.05).Magnetic sensitive scan showed depression group compared with the control group was significantly reduced in lateral vein diameter,length and branches (t value were 3.23,4.56,2.66,P＜0.05).Conclusion The SWI sequence and 1H-MRS imaging methods can become a new research idea about the central nucleus,and this idea may explain the causal relationship between the hippocampus in depression patients of vascular abnormalities and hippocampal neuronal metabolic abnormalities.
