Molecular analysis of a single nucleotide polymorphism in SCL17A1 and uric acid levels in Uyghur patients with hyperuricemia in Xinjiang region

VernacularTitle:新疆维吾尔族高尿酸血症患者SLC17A1基因单核苷酸多态性与尿酸水平的关系
Author: Yan MA ; Yinxia SU ; Tingting WANG ; Zhiqiang WANG ; Qi MA ; Shuxia WANG ; Hua YAO
Publication Type:Journal Article
Keywords: Uyghur; Hyperuricemia; SLC17A1; Polymorphism,single nucleotide
From: Chinese Journal of Endocrinology and Metabolism 2015;31(3):254-256
CountryChina
Language:Chinese
Abstract: The association between the polymorphism of SLC17A1 gene and hyperuricemia in Uyghur population in Xinjiang region was explored by Chi-square test.A total of 1 024 patients with hyperuricemia and 1 033 healthy volunteers were included.The genotype frequencies of CC,CT,and Tr in hyperuricemia and healthy controls were 24.9％,53.14％,21.96％ and 29.7％,47.52％,22.77％,respectively.There was statistical difference in SLC17A1 rs9467596 genotype frequencies between hyperuricemia cases and controls (x2 =7.492,P =0.024).CT genotype could increase the risk of hyperuricemia compared with CC genotype (OR =1.334,95％ CI 1.082-1.644).No statistical significance among the genotypes was found in age,body mass index,blood pressure,blood glucose,triglyceride,total cholesterol,High-density lipoprotein-cholesterol,low-density lipoprotein-Cholesterd,blood urea nitrogen,and Creatinine.The polymorphism of rs9467596 in SLC17A1 may be a genetic marker to assess risk of hyperuricemia among Xinjiang Uyghur population.