Advance in optogenetic application of cocaine addiction mechanisms
10.3760/cma.j.issn.1674-6554.2015.06.026
- VernacularTitle:光遗传技术在可卡因成瘾机制中的应用
- Author:
Cunxia FAN
;
Yi CAI
;
Tingting YANG
;
Miaoliang CHEN
;
Kangrong LU
;
Wanshan WANG
- Publication Type:Journal Article
- Keywords:
Optogenetic;
Addiction;
Photosensitive proteins;
Cocaine
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(6):573-576
- CountryChina
- Language:Chinese
-
Abstract:
Objective To integrate existing data and analyze the optogenetic application in the study of the cocaine addiction mechanism.Methods The key words optogenetics,addiction, cocaine and so on were selected.Relevant research information was collected from various authentic databases such as China Journal Full-text Database,Chinese Biomedical Databases,Wanfang Digital Journals,VIP Full-text Database and PubMed,SCIENCEDIRECT,SPRINGERLINK databases by literature study,assess the quality of the studies and the qualitative systematic review was conducted in this study.Results Findings from present data showed that:with great spatial and temporal specificity,the optogenetic application not only proved the important role of traditional theories of mesolimbic dopamine system,but also dissected the neural circuits and molecular mechanisms of dopaminergic and glutamatergic neurotransmission underlying cocaine addiction.Conclusion The use of optogenetic tools has given researchers the potential to dissect the neuronal circuits and molecular changes,leading us to a better understanding of the mechanisms of cocaine addiction and to the development of novel treatment.
