Survival analysis of 159 patients with hepatic encephalopathy in acute-on-chronic liver failure
10.3760/cma.j.issn.1008-6706.2015.09.010
- VernacularTitle:慢加急性肝衰竭合并肝性脑病159例生存分析
- Author:
Yanping CUI
;
Xia CUI
;
Shan GUAN
;
Qingfang LI
;
Sikui WANG
- Publication Type:Journal Article
- Keywords:
Liver failure;
Hepatic encephalopathy;
Factor analysis,statistical
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(9):1309-1312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the prognostic factors for patients with hepatic encephalopathy (HE) in acute-on-chronic liver failure(ACLF).Methods A retrospective analysis was performed on 159 ACLF patients with HE.The hepatic encephalopathy was determined to baseline,the patients were divided into survivors(n =13) and nonsurvivors(n =146),The 32 factors affecting the prognosis were analyzed by Cox proportional hazard model with SPSS.Results One-month,three-month,and six-month survival rates were 20.13％,10.06％ and 8.18％,respectively.Cox regression analysis of prognostic factors showed that it could the stage of hepatic encephalopathy and HRS significantly improve the survival rate of the patients with HE in acute-on-chronic liver failure.The stage of hepatic encephalopathy and HRS could significantly decrease the survival rate of the patients(x2 =18.344,11.368,all P ＜ 0.05),elevated the levels of hepatic encephalopathy (relative risk (RR) =1.591) and HRS (RR =1.809) indicate worse prognosis with hepatic encephalopathy in acute-on-chronic failure.Conclusion The stage of hepatic encephalopathy and HRS were independent risk factor sof prognosis in acute-on-chronic liver failure.
